There are properties that simply cannot be replicated. Privately sited on 7.7 waterfront acres on Portsmouth's coveted Shapleigh Island, 518 New Castle Avenue is a once-in-a-generation New England estate, an extraordinary convergence of scale, privacy, architecture, and waterfront living just moments from the heart of downtown Portsmouth. With 13,450± square feet, this magnificent Shingle Style residence was conceived on a grand scale, pairing timeless coastal architecture with exceptional craftsmanship and sophisticated modern living. Georgian-inspired millwork, stately Tuscan columns, intricate wainscoting, and beautifully proportioned interiors create a residence of remarkable presence, while walls of windows capture sweeping water views and an ever-changing maritime landscape. Across 17 rooms, the estate offers 6 bedrooms, 7 full and 2 half baths, and an impressive collection of formal and informal living spaces equally suited for everyday living and grand-scale entertaining. A newly added balcony overlooking the pool creates an elevated vantage point of the estate's sweeping water views. Beyond the home, manicured grounds descend toward the Piscataqua River, where a private deep-water dock provides direct access to Portsmouth Harbor and the open Atlantic beyond. An attached 3-car garage is complemented by a separate 3-car garage with a finished 1-bedroom, 1-bath guest accommodation above, creating a private and flexible retreat for visitors. Nearly 6,000 square feet of unfinished lower-level space offers exceptional flexibility and storage, while a new roof completed in 2025 represents a significant recent improvement. Yet perhaps the estate's greatest luxury is one that cannot be recreated: complete seclusion across 7.7 waterfront acres while remaining connected to downtown Portsmouth and its cultural, culinary, and coastal lifestyle. 518 New Castle Ave is a landmark NH estate and a rare opportunity to steward one of the region's defining legacy properties.